14th SLC MeetingPozzilli, ItalySeptember 7-11, 2022

ABOUT

Sphingolipids have been first described as one of the major structural constituents of biological membranes. However, their functional role has attracted increased attention over the years.

They are crucial in the control of cell survival and differentiation by regulating several molecular and biochemical pathways.

The Sphingolipid Club International Meeting will cover all the topics associated with sphingolipids, ranging from their biochemical and biophysical properties to the development of new technologies and applications. Particular attention will be also paid to the role of sphingolipids in both human health and disease conditions with the aim to provide a global scenario of emerging role of sphingolipids in translational medicine.

This Meeting will bring together well-established experts and young investigators and will be open to researchers from outside the field, who have recently become interested in sphingolipid biology. As we did in previous Meeting, we plan to offer some travel grants for selected oral presentations and posters by young trainees.

All this will provide a vibrant, interdisciplinary and cross-generational environment which will allow all the participants to share their “sphingolipid vision” and to establish new fruitful and exciting collaborations.

Registration deadline

June 15, 2022

Late Registration

Late registration is still possible. If interested, send an email to info@sphingolipidclub.com

Abstract Submission deadline

July 30,  2022

Registration closed

LOCATION

The Meeting venue is the Neuromed Research Center, via dell’Elettronica, Pozzilli, Isernia – Italy

About the area

Molise is the second smallest region in Italy. Typical inland and mountainous region, it is the most unexplored region of Italy. The offer is very attractive: mountains, sea, lakes, tratturi (the ancient, seasonal trails used to move livestock between pastures), historical sites.

In Roman times, Molise was the home to the notorious Samnites, a people famously portrayed by the Romans as strong gladiators. The famous sanctuary of Pietrabbondante in the north is considered the most important cult site of the Samnite state. The view from the surviving theater looking out over the countryside is spectacular.

Isernia is the second Province town in Molise, the first one being Campobasso. Isernia offers some interesting monuments. The Paleolithic Museum preserves some of the earliest evidence of Samnites habitation.  The museum is built on one of the most important Prehistoric archaeological sites in the Mediterranean world. Other places to be visited are the monumental Fontana Fraterna, the Cathedral of St. Peter and Apostle, the Civic Tower and the San Francesco Palace.

Pozzilli, where Neuromed is located, is a small municipality situated in the Volturno Valley just below the Mainarde mountains. Thanks to a good connection between farming, industries and infrastructures, Pozzilli is one of the few municipality with a rise in population. The facility of Neuromed Research Center located in Pozzilli is situated inside a monumental and cultivated olive tree garden. A legend says the olive tree was introduced in Venafro and Pozzilli by Licinius, a Roman veteran farmer, after whom the local “Licinian” olive is named. The incredible strong DNA was able to resist to climatic and parasitic adverse conditions over hundreds and thousands of years. In the contemporary period of time the oil has been rediscovered thanks to its universally recognized qualities in both therapeutic and preventive areas associated to aging-related diseases.

Culinary and wine tours in Molise are also a very authentic experience, the territory has its agriculture vocation for the growth of vines and olive trees.  Interestingly, Molise is the land of “the white gold”, since one of the biggest white truffle in the world (1.2 kg) was found in this region.

ACCOMODATION

Accomodation for 4 nights (Sept. 7 to 11, 2022) is included in the Registration fee, as well as all lunches, coffee breaks and dinners during the Meeting.

Participants will be accomodated at Grand Hotel Europa,  a 4-stars Hotel, in Isernia, at a 20-min bus distance from the Meeting Venue. An american or continental breakfast is included.

A free shuttle service will be available to reach the Meeting venue on morning and late afternoon, after scientific sessions. 

TRANSPORT

By plane

The nearest airport is Napoli Capodichino, 81 km from Pozzilli and 107 km from Isernia, daily connected with most International airports. On demand, bus transfers will be arranged by the organizers closer to the flight arrival time, on Sept. 7 afternoon and evening. Report your interest on this while registering, and you will be re-contacted. Departure bus transfer on Sept 11 morning from the Meeting venue to Napoli Capodichino airport will be planned on demand during the Meeting.

Several rent-a-car companies are active at the airport.

By car

To reach both Pozzilli and Isernia, you must take highway Adriatica A2-Autostrada del Sole. Coming from Rome take the exit San Vittore and follow the indications to Venafro and then Pozzilli and Isernia. Coming from Naples take the exit Caianello, then take the SS85 in direction to Venafro and then Pozzilli and Isernia.

By train

The closest station to Pozzilli is Venafro, 4 km distant from the Meeting venue. The Venafro railway station is well connected with Naples Central Station and Roma Termini Station. Generally the trip is less than two-hours long.

To reach the Grand Hotel Europa the closest railway station is Isernia, well connected with Naples Central Station and Roma Termini Station. The trip takes approximately two hours.

Check the train timetables on the Italian Railways official site.

REGISTRATION

Registration deadline

June 15, 2022

Late registration

Late registration is still possible. If interested, send an email to info@sphingolipidclub.com

Abstract Submission deadline

July 30,  2022

The Registration fee for active participants and accompanying persons includes:

Active participants

Accompanying persons

Accomodation at Grand Hotel Europa, Isernia on Sept 7 to 11, 2022

YES YES

Lunches during the Meeting

YES NO

Welcome buffet and dinners during the Meeting

YES YES

Coffee breaks during the Meeting

YES NO

Gala dinner on Sept. 10

YES YES

Participation to the Social Program on Sept 9

YES YES

Meeting Material

YES NO

Admission to all Meeting sessions

YES NO

Registration fee payment receipt (not invoice)

YES YES

Official Attendance certificate

YES NO

Please click on REGISTER NOW, fill the Form, save as PDF file and pay by bank transfer.

Send an e-mail to info@sphingolipidclub.com (deadline June 15, 2022), attach the Form and the payment receipt (and for Juniors the status certificate).

Registration will be confirmed within 7 days.

You can find Bank details in the form.

Late registration is still possible. If interested, send an email to info@sphingolipidclub.com

Accomodation special requirements:

If you need additional nights, one or two nights only or no accomodation, please specify your needs in the below space of the registration form, and wait for our reply for the recalculation of the registration fee.

Registration closed

ABSTRACT SUBMISSION

Only registered participants attending the event are eligible to submit an abstract. 

To submit your contribution, send an email to info@sphingolipidclub.com , specifying if you wish to give an oral communication or present a poster and attaching a File Word with your Abstract.

Your Abstract should be written in English, using Times New Roman, font 12  and should contain:

A TITLE, BOLD CHARACTER, CAPITAL LETTERS, WITHOUT ABBREVIATIONS

The list of authors, with the initial of the first name and full surname, in bold character. The presenting author should be outlined

Affiliation  of each author, in Italics. Do not insert address of the Institution or email of the authors 

Text. Maximum: 25 lanes. Do not put figures, references, and acknowledgements, unless absolutely necessary.  On your choice you could divide the text in subheadings (Introduction, Experimentals, Results, Conclusions) 

PROGRAM

Grand Hotel Europa, Isernia

14:00 – 20:30 Welcoming and Registration

20:30 –  Light dinner

Neuromed Research Center, Pozzilli

09:00 - 09:05 Welcome greetings

Luigi Frati  Scientific Director IRCCS Neuromed

Giovanni de Gaetano  President IRCCS Neuromed

09:05 - 09:15 Opening remarks

                        Vittorio Maglione, Alba Di Pardo (IRCCS Neuromed, IT)

09:15 - 09:50 Keynote Lecture                        

                        Timothy Cox (University of Cambridge, UK)

  Sphingolipids – classical matters in the ancient and modern world

09:50 - 11:45 Session 1 - Sphingolipids in health and disease (I)

            Chairs: Marco Presta (Brescia, IT), Carmen Garcia-Ruiz (Barcelona, ES)

09:50 - 10:15 Lauren Ashley Cowart (Virginia Commonwealth University, US)

 Sptlc3 and novel sphingolipids in health and disease

10:15 - 10:30 Duyen Tran (University of Tasmania, AU)

Toxic 1-deoxysphinganine, compromises the functionality of skeletal myoblasts and underlies the development of type 2 diabetes mellitus

10:30 - 10:45 Anna Kovilakath (Virginia Commonwealth University, US)

The novel sphingolipid enzyme SPTLC3 ameliorates ischemic failure by reducing reactive oxygen species

10:45 - 11:00 Marcelo Einicker-Lamas (Universidade Federal do Rio de Janeiro, BR)

                       Sphingosine-1-phosphate prevents human embryonic stem cell death

following ischemic injury 

11:00 - 11:15 Coffee break

11:15 - 11:30 Isabelle Seidita (University of Florence, IT)      

Sphingosine-1-phosphate acts as a pro-inflammatory cue in human endometrial stromal cells acting via ERK5: implication in endometriosis

11:30 - 11:45 Zoltan Benyo (Semmelweis University, HU)

Identification of signaling pathways mediating coronary flow reduction induced by sphingosine-1-phosphate

11:45 - 12:45 Session 1 - Sphingolipids in health and disease (II)

Chairs: Lauren Ashley Cowart (Richmond, US), Philippe Guerre (Toulouse, FR)

11:45 - 12:00 Valentine Yolander (Virginia Commonwealth University, US)

Sphingosine kinase 1 and sphingosine-1-phopshate receptor function in adipocyte beiging

12:00 - 12:15 José Fernandez-Checa (University of Barcelona, ES)

Dietary and genetic disruption of hepatic methionine metabolism induces acid sphingomyelinase expression to promote steatohepatitis

12:15 - 12:30 David Montefusco (Virginia Commonwealth University, US)

SPTLC3 and atypical sphingolipids as regulators of hepatic glucose production

12:30 - 12:45 Mariana Nikolova-Karakashian (University of Kentucky, US)

Role of neutral sphingomyelinase 2 in fatty liver disease and insulin resistance

12:45 - 14:20 Lunch

14:20 - 15:55   Session 1 - Sphingolipids in health and disease (III)

  Chairs: Thierry Levade (Toulouse, FR), Chiara Donati (Florence, IT)

14:20 - 14:45 Diego Centonze (IRCCS Neuromed and University of Rome Tor Vergata, IT)

Inflammatory synaptopathy as a novel target of S1P receptor modulation in experimental multiple sclerosis

14:45 - 15:00 Mirek Machala (Veterinary Research Institute, CZ)

Sphingolipid and glycosphingolipid profiles are altered during benzo[a]pyrene-induced epithelial-mesenchymal transition of normal human bronchial epithelial cells, as well as in their exosomes

15:00 - 15:25 Andrea Huwiler (University of Bern, CH)

The role of Sphingosine kinase 2 in chronic kidney disease

15:25 - 15:40 Christiane Mühle (University of Erlangen DE)

COVID-19 and its clinical severity are associated with alterations of plasma sphingolipids and enzyme activities of sphingomyelinase and ceramidase

15:40 - 15:55 Trushnal Waghmare (University of Würzburg, DE)

Role of neutral sphingomyelinase 2 and sialophorin as virus effector in T cells

15:55 - 17:20   Session 2 - Sphingolipids and malignant diseases (I)

Chairs: Christiane Mühle (Erlangen, DE), Michele Dei Cas (Milan, IT)

15:55 - 16:20 Marco Presta (University of Brescia, IT)

Beta-Galactosylceramidase: more than a psychosine scavenger

16:20 - 16:35 Hui-Ming Lin (Garvan Institute of Medical Research, AU)

Modulation of circulating sphingolipids in metastatic prostate cancer by simvastatin

16:35 - 16:50 Coffee break

16:50 - 17:05 Giovanna Chiorino (Fondazione Edo ed Elvo Tempia, Biella, IT)

Targeted sphingolipid analysis to improve prostate cancer detection

17:05 - 17:20 Lorry Carrié (Université Toulouse III Paul-Sabatier, FR)

Tumor cell-derived sphingosine 1-phosphate promotes loss of adhesion to keratinocytes and contributes to primary melanoma invasion

17:20 - 18:35 Session 2 – Sphingolipids and malignant diseases (II)

Chairs: Gehrild Van Echten-Deckert (Bonn, DE), Angel Gaudioso (Madrid, ES)

17:20 -17:35 Carine Dufau (Université de Toulouse III Paul-Sabatier, FR)

Role of ceramide metabolism in TNF-induced melanoma dedifferentiation

17:35 - 17:50   Davide Capoferri (University of Brescia, IT)

Beta-galactosylceramidase modulates the pro-oncogenic features of melanoma cells

17:50 - 18:05 Chiara Raggi (University of Florence, IT)

Irregular glycosphingolipid patterns in human cholangiocarcinoma stem-like subsets

18:05 - 18:20 Francois Paris (Université de Nantes, FR)

Release of ceramide by irradiated endothelial cell inhibits tumor cell proliferation after repression of Lamin B1 expression

18:20 - 18:35 Sumaiya Afsar (University of Bonn, DE)

SGPL1 ablation affects glucose metabolism in a way that abets oncogenesis

20:30 - Dinner

Neuromed Research Center, Pozzilli

9:00 - 11:05 Session 3 - Sphingolipid biology: mechanisms and tools (I)

Chairs: Francois Paris (Nantes, FR), Andrea Huwiler (Bern, CH)

09:00 - 09:25 Antonella De Matteis (Telethon Institute of Genetics and Medicine, IT)

ER-Golgi contact sites: regulators and targets of sphingolipids

09:25 - 09:40 Marco Trinchera (University of Insubria, IT)

Bi-allelic inactivating variants of Lactosylceramide Synthase beta4GALT5 responsible for a novel congenital disorder of glycosylation involving glycosphingolipids

09:40 - 09:55 Roxana Manaila (University of Bern, CH)

Sphk1 and sphk2 differentially regulate erythropoietin synthesis in mouse renal interstitial fibroblast-like cells

09:55 - 10:10 Tanes Imamura de Lima (École Polytechnique Fédérale de Lausanne, CH)

Inhibition of de novo ceramide synthesis restores mitochondrial and protein homeostasis in muscle aging

10:10 - 10:25 Caterina Giovagnoni (Maastricht University, NL)

Function of ceramide transfer protein for biogenesis and sphingolipid composition of extracellular vesicles

10:25 - 10:50 Webster Santos (Virginia Tech, US)

Discovery, structure-activity relationship studies, and in vivo activity of sphingosine-1-phosphate transporter spns2

10:50 - 11:05 Michele Dei Cas (University of Milan, IT)

Mass spectrometry measurement of sphingolipids delta-4-desaturase 1 activity and its application in related genetic diseases

11:05 - 11:20 Coffee break

11:20 - 13:00 Session 3 – Sphingolipid biology: mechanisms and tools (II)

                        Chairs: Dagmar Meyer zu-Heringdorf (Frankfurt, DE), Massimo Aureli (Milan, IT)

11:20 - 11:35 Philippe Guerre (ENVT Toulouse, FR)

Targeted sphingolipid analysis suggests mechanisms of fumonisin toxicity in chickens    

differs depending on the organ studied

11:35 - 12:00   Tsaffrir Zor (Tel Aviv University, IL)

Short fatty acid sulfatides are endogenous ligands for TLR4/MD-2

12:00 - 12:15 Tristan Martineau (Université de Sherbrooke, CA)

Urine screening test using a tandem mass spectrometry approach for early detection of lysosphingolipidoses

12:15 - 12:30 Camillo Morano (University of Milan, IT)

A new “how to” in sphingolipidomics as a tool for a common sample handling and analysis 

12:30 - 12:45 Essa M. Saied (Humboldt-Universität zu Berlin, DE)

Discovery of the first selective and drug-like small molecule inhibitors of Alkaline Ceramidase 3

12:45 - 13:00 Stefano Piotto (University of Salerno, IT)

Mechanistic study of the role of hydroxylation of sphingolipids

13:00 - 15:00 Lunch and Poster viewing

15:00 - 20:30 Social time: Picture time and visit to Agnone

20:30 - Dinner

Neuromed Research Center, Pozzilli

09:00 – 13:00 ISN Symposium: Sphingolipids and brain: pathophysiology and therapeutics

Chairs: Alba Di Pardo, Vittorio Maglione (Pozzilli, IT)

09:00 - 09:10 Introduction by Chairs

09:10 - 09:35 Simonetta Sipione (University of Alberta, CA)

Gangliosides: old dogs with new tricks

09:35 - 10:00 Massimo Aureli (University of Milan, IT)

Role of the lysosomal impairment in the onset of neuronal degeneration

10:00 - 10:25 Wiebke Herzog (University of Erlangen, DE)

Regulation of blood-brain barrier properties by Sphingosine-1-phosphate signaling

10:25 - 10:50 Eric Camerer (Université Paris Cité, FR)

Tight control of S1P signaling at the blood-brain barrier

10:50 - 11:05 Coffee break

11:05 - 11:30 Pilar Martinez-Martinez (University of Maastricht, NL)

Title not available

11:30 - 11:45 Angel Gaudioso (Centro Biologia Molecular Severo Ochoa (CSIC-UAM), Madrid, ES)

Sphingomyelin 16:0 is a therapeutic target for brain pathology in Acid Sphingomyelinase deficiency

11:45 - 12:00 Liubov Kalinichenko (University of Erlangen, DE)

Ceramide system contributes to learning and memory

12:00 - 12:15 Daan Van Kruining (Maastricht University, NL)

FTY720 decreases ceramide levels in the brain and prevents memory impairments in a mouse model of familial Alzheimer's disease expressing ApoE4

12:15 - 12:30 Sara Grassi (University of Milan, IT)

Sphingolipid-dependent membrane organization and signaling orchestrating myelin repair

12:30 - 12:45 Giuseppe Pepe (IRCCS Neuromed, IT)

Treatment with THI, an inhibitor of Sphingosine-1-Phosphate Lyase (SGPL1), modulates glycosphingolipid metabolism and results therapeutically effective in a mouse model of Huntington’s disease

12:45 - 13:00 Shah Alam (University of Bonn, DE)

S1P-lyase deficiency in the brain increases glucose breakdown evoking a P2Y1 Receptor-dependent astrogliosis

13:00 - 14:00 Lunch

14:00 - 15:00 Poster flash presentations (2 slides in 2 min)

Chair: Riccardo Ghidoni (Milan, IT)

Gloria Grelle M.R.S. (Universidade Federal do Rio de Janeiro, BR)

LC-HRMS-based sphingolipid profiling of renal cells exposed to ischemia

Dragana Fabris (University of Zagreb, HR)

Ceramides and sphingomyelins in ischemic stroke: a preliminary study

Gloria Grelle M.R.S. (Universidade Federal do Rio de Janeiro, BR)

Ceramide-1-Phosphate as a potential regulator of the second sodium pump from kidney proximal tubules through different protein kinase pathways

Luisa Volk (Universität of Frankfurt am Main, DE)

Functional consequences of sphingosine-1-phosphate lyase deletion in mouse hepatocytes

Samuela Cataldi (University of Perugia, IT)

Egg yolk sphingomelin facilitates the maturation of hippocampal embryonic cells

Federico Fiorani (University of Perugia, IT)

Exosomes amplify the signal of vitamin D3-induced embryonic hippocampal cell differentiation via ceramide

Tommaso Beccari (University of Perugia, IT)

Neuroprotective effect of Eicosapentaenoic acid and Docosahexaenoic acid on SH-SY5Y cells

Michele Dei Cas (University of Milan, IT)

Altered sphingolipid content in extracellular vesicles derived from primary intrahepatic cholangiocarcinoma cells

Marzia Corli (University of Brescia, IT)

Unravelling the role of β-galactosylceramidase in melanoma neovascularization

Ondreji Kovac (Veterinary Research Institute, CZ)

Possible role of the aryl hydrocarbon receptor in modulation of sphingolipid and glycosphingolipid metabolism in colon cancer cell models

Josè Luis Abad (CSIC Barcelona, ES)

Fluorescent ceramide-labeled probes with bodipy and coumarin-based coupy fluorophores

Alix Pierron (ENVT Toulouse, FR)

Targeted sphingolipid analysis reveals differences on wild type mouse and SOCS2 deficient mouse in peritonitis zymosan induced

Christiane Mühle (University Erlangen, DE)

Interplay of sphingolipids and α-synuclein in Parkinson’s disease and major depressive disorder

Lucia Sessa (University of Salerno, IT)

The influence of hydroxylation in the mechanism of action of α-hydroxy-ceramide

Bisera Stepanovska Tanturovska (University of Bern, CH)

S1P stimulates erythropoietin production in mouse renal interstitial fibroblasts by S1P1 and S1P3 receptor activation and HIF-2α stabilization

Karoli Liliom (Semmelweis University, HU)

Apolipoprotein D is a lipocalin carrier protein for lysophospholipid mediators

Gemma Fabrias (CSIC Barcelona, ES)

A novel fluorogenic probe to monitor the activity of acid ceramidase, fatty acid amide hydrolase and N-acylethanol-amine acid amidase

Salvatore Fiorinello (National Research Council of Italy, Napoli, IT)

Pharmacological treatment with sphingosine analogues to correct glycosphingolipid metabolic derangements in Rett syndrome models

Christiane Mühle (University Erlangen, DE)

Sphingomyelin synthases in depression and antidepressant treatment

Fabrizia Noro (IRCCS Neuromed, IT)

The effect of gangliosides on human platelet aggregation and platelet-leukocyte mixed aggregate formation

15:00 - 15:15 Coffee break

15:15 – 16:30 Laboratories guided tour

Neuromed Research Center

16:30 - 18:00 Session 4 – Sphingolipids and brain 2.0

Chair: Simonetta Sipione (Edmonton, CA), Eric Camerer (Paris, FR)

16:30 - 16:55 Christian Müller (University of Erlangen, DE)

Neutral Sphingomyelinase in the control of alcohol abuse and its comorbidities

16:55 - 17:10 Floriana Della Ragione (National Research Council of Italy, Napoli, IT)

Imbalance of glycosphingolipid metabolism in Rett Syndrome as a novel potential therapeutic target

17:10 - 17:35 Thorsten Hornemann (USZ, Zürich, CH)

Motor neuron disease or sensory neuropathy? L-Serine as a modulating factor

17:35 - 18:00 Alessandra D’Azzo (St. Jude Children’s Research Hospital, Menphis, US)

Role of membrane contact sites in the neuropathogenesis of GM1-Gangliosidosis

20:30 - Gala dinner and live entertainment

Grand Hotel Europa, Isernia

09:00 – 10:00 General Meeting of the Sphingolipid Club

10:00 – 10:15 Closing remarks

ANTONIO DELGADO AWARD

Prof. Antonio Delgado, from the Department of Pharmacology and Therapeutic Chemistry of the University of Barcelona, passed away on last Dec. 23, 2021.

In view of Antonio precious contribution in sphingolipid chemistry, the Sphingolipid Club is pleased to offer a 500 € Award to be selected among all oral communications and posters focused on “Chemistry in Sphingolipid Research”, presented by young researchers (PhD and postdocs) at the next XIV Sphingolipid Club Meeting.

Applicants should simply communicate their interest in this Award just upon arrival at the Meeting venue, at the Registration desk, and the title of their presentation.

Selection will be made by a jury composed by Gemma Fabrias and by two other components, one from the Youth Board and the other from the Scientific Board, attending the Meeting and nominated successively.

The name of the winner will be notified during the Gala Dinner on Sept. 10.

MARK KESTER AWARD

Prof. Mark Kester, from the Department of Pharmacology and Director of the NanoSTAR Institute of the University of Virginia, passed away on last July 20, 2022.

In view of Mark precious contribution in the Sphingolipid research, the Sphingolipid Club and Neuromed are pleased to announce the call for two 500 € Awards on “Sphingolipid signaling in Cancer”, presented by young researchers (PhD and postdocs) at the next XIV Sphingolipid Club Meeting.

One of these Award is possible thanks to the generous contribution of Prof. Myles Cabot, a close friend of Prof. Kester

Applicants should simply communicate their interest in these Awards just upon arrival at the Meeting venue, at the Registration desk, with the title of their presentation.

Selection will be made by a jury composed by a component of our Youth Board and by two other components, from the Scientific Board Members, attending the Meeting.

The name of the winners will be communicated during the Gala Dinner on Sept. 10.

CONTACTS

Registration: info@sphingolipidclub.com

Scientific Committee: vittorio.maglione@neuromed.it, alba.dipardo@neuromed.it

Local secretary: Emilia Belfiore emibelf@yahoo.it and Domenica Berardi dimp@neuromed.it